Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 1.00 |
| ▸ | PDE6D | O43924 | 2/20 | 1.00 |
| ▸ | PDE8A | O60658 | 2/20 | 1.00 |
| ▸ | PDE5A | O76074 | 2/20 | 1.00 |
| ▸ | PDE9A | O76083 | 2/20 | 1.00 |
| ▸ | PDE8B | O95263 | 2/20 | 1.00 |
| ▸ | PDE6A | P16499 | 2/20 | 1.00 |
| ▸ | PDE6G | P18545 | 2/20 | 1.00 |
| ▸ | PDE4A | P27815 | 2/20 | 1.00 |
| ▸ | PDE6B | P35913 | 2/20 | 1.00 |
| ▸ | PDE6C | P51160 | 2/20 | 1.00 |
| ▸ | PDE1A | P54750 | 2/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 2/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 2/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 2/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 2/20 | 1.00 |
| ▸ | PDE7A | Q13946 | 2/20 | 1.00 |
| ▸ | PDE6H | Q13956 | 2/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30273078 | 0.81 | PDE2A (0.69) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL2818529 | 0.81 | PDE2A (0.69) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL8566230 | 0.80 | PDE2A (0.67) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL30809703 | 0.80 | PDE2A (0.67) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL249873 | 0.74 | PDE2A (0.59) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL5549672 | 0.74 | PDE2A (0.58) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL21617342 | 0.73 | PDE3B (0.58) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL14431586 | 0.73 | PDE2A (0.58) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL6428774 | 0.72 | PDE2A (0.56) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL25403036 | 0.71 | PDE5A (0.56) | PDE2APDE6DPDE8APDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400583-B1 | Imidazoquinoxalinones, their aza analogs and process for their preparation | BERLEX LAB (US) | 1999-11-17 | — | — | EP | claimed |
| US-5055465-A | IMIDAZOQUINOXALINONES, THEIR AZA ANALOGS AND PROCESS FOR THEIR PREPARATION | BERLEX LABORATORIES, INC. (US) | 1991-10-08 | — | — | US | claimed |
| EP-0400583-A1 | Imidazoquinoxalinones, their aza analogs and process for their preparation | BERLEX LABORATORIES, INC. (US) | 1990-12-05 | — | — | EP | claimed |