Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.67 |
| ▸ | PDE6D | O43924 | 2/20 | 0.67 |
| ▸ | PDE8A | O60658 | 2/20 | 0.67 |
| ▸ | PDE5A | O76074 | 2/20 | 0.67 |
| ▸ | PDE9A | O76083 | 2/20 | 0.67 |
| ▸ | PDE8B | O95263 | 2/20 | 0.67 |
| ▸ | PDE6A | P16499 | 2/20 | 0.67 |
| ▸ | PDE6G | P18545 | 2/20 | 0.67 |
| ▸ | PDE4A | P27815 | 2/20 | 0.67 |
| ▸ | PDE6B | P35913 | 2/20 | 0.67 |
| ▸ | PDE6C | P51160 | 2/20 | 0.67 |
| ▸ | PDE1A | P54750 | 2/20 | 0.67 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.67 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.67 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.67 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566230 | 1.00 | PDE2A (0.67) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL7269656 | 0.80 | PDE2A (1.00) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL8566784 | 0.79 | PARP1 (0.49) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL249873 | 0.78 | PDE2A (0.59) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL25403036 | 0.76 | PDE5A (0.56) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL708266 | 0.76 | PARP1 (0.50) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL1133601 | 0.75 | PARP1 (1.00) | PARP1DAOTP53GRIN2DGRIN3B | |
| SCHEMBL29673205 | 0.75 | PARP1 (1.00) | PARP1DAOTP53GRIN2DGRIN3B | |
| SCHEMBL30273078 | 0.75 | PDE2A (0.69) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL2818529 | 0.75 | PDE2A (0.69) | PDE2APDE6DPDE8APDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12551580-B2 | Heterocyclic compounds and imaging agents for imaging Huntington protein | CHDI FOUNDATION, INC. (US) | 2026-02-17 | — | — | US | disclosed |
| US-20240342317-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2024-10-17 | — | — | US | disclosed |
| US-11918662-B2 | Heterocyclic compounds and imaging agents for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11918662-B2 | Heterocyclic compounds and imaging agents for imaging huntingtin protein | HTT, HYPK, HSPBP1 | PDE2A 3793/4885PDE6D 4068/4885PDE8A 1250/4885 |
| US-12551580-B2 | Heterocyclic compounds and imaging agents for imaging Huntington protein | HTT, HYPK, HIRA | PDE2A 4474/4885PDE6D 3692/4885PDE8A 2266/4885 |
| US-20240342317-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | PDE2A 3793/4885PDE6D 4068/4885PDE8A 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.