Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11687983 | 0.79 | FASN (0.53) | FASNSLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL24137898 | 0.76 | MEN1 (0.62) | SLC6A2SLC6A4SLC6A3TAAR1DRD4 | |
| SCHEMBL2077308 | 0.76 | MEN1 (0.62) | SLC6A2SLC6A4SLC6A3TAAR1DRD4 | |
| SCHEMBL52143 | 0.76 | MEN1 (0.62) | SLC6A2SLC6A4SLC6A3TAAR1DRD4 | |
| SCHEMBL3761884 | 0.74 | FASN (0.49) | FASNSLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL7428125 | 0.74 | DRD4 (0.47) | SLC6A2SLC6A4SLC6A3TAAR1DRD4 | |
| SCHEMBL8786930 | 0.74 | SLC6A2 (0.50) | FASNSLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL1493179 | 0.74 | FASN (0.49) | FASNSLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL8200189 | 0.74 | SLC6A2 (0.50) | FASNSLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL5864654 | 0.74 | SLC6A2 (0.50) | FASNSLC6A2SLC6A4SLC6A3TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |