Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5112508 | 0.86 | MEN1 (0.60) | MEN1KMT2ALMNAMMEACE | |
| SCHEMBL4971618 | 0.85 | NPSR1 (0.67) | MEN1KMT2ALMNANPSR1TSHR | |
| SCHEMBL30808619 | 0.85 | NPSR1 (0.67) | MEN1KMT2ALMNANPSR1TSHR | |
| SCHEMBL7280026 | 0.83 | NPSR1 (0.62) | MEN1KMT2ALMNANPSR1TSHR | |
| SCHEMBL30808640 | 0.81 | KMO (0.55) | MEN1KMT2ALMNATSHRMAPT | |
| SCHEMBL30808610 | 0.81 | KMO (0.58) | MEN1KMT2ALMNANPSR1ALDH1A1 | |
| SCHEMBL30808599 | 0.81 | TSHR (0.46) | MEN1KMT2ALMNANPSR1TSHR | |
| SCHEMBL9850726 | 0.81 | NPSR1 (0.50) | MEN1KMT2ALMNANPSR1TSHR | |
| SCHEMBL30808648 | 0.80 | MEN1 (0.63) | MEN1KMT2ALMNANPSR1TSHR | |
| SCHEMBL12963502 | 0.80 | NPSR1 (0.60) | LMNANPSR1TSHRALDH1A1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250002-A1 | IDENTIFICATION OF NOVEL BENZOTHIAZONES AS TAU-SH3 INTERACTION INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | SOUTHERN RESEARCH INSTITUTE (US) | 2023-12-28 | — | — | WO | disclosed |
| EP-0411751-A1 | Renin inhibitory peptides | Beecham Group p.l.c. (GB) | 1991-02-06 | — | — | EP | disclosed |