Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 9/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 4/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | Q9HBH1 | 1/20 | 0.33 | |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269778 | 1.00 | CTSC (0.38) | CTSCRENCTSKP2RX1POLB | |
| SCHEMBL9555719 | 0.85 | CTSC (0.46) | CTSCRENP2RX1 | |
| SCHEMBL9555727 | 0.85 | CTSC (0.46) | CTSCRENP2RX1 | |
| SCHEMBL7278389 | 0.84 | CTSC (0.35) | CTSCRENCTSKPOLBGCK | |
| SCHEMBL7278383 | 0.84 | CTSC (0.35) | CTSCRENCTSKPOLBGCK | |
| SCHEMBL7277211 | 0.83 | HSPA5 (0.36) | CTSCRENGCK | |
| SCHEMBL7277204 | 0.83 | HSPA5 (0.36) | CTSCRENGCK | |
| SCHEMBL7316736 | 0.83 | REN (0.36) | REN | |
| SCHEMBL7290665 | 0.82 | P2RX1 (0.46) | RENP2RX1 | |
| SCHEMBL7281025 | 0.82 | P2RX1 (0.44) | RENP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |