Betamethasone Valerate

Betamethasone Valerate

SCHEMBL7270

CCCCC(=O)O[C@]1(C(=O)CO)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Betamethasone Valerate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 known ✓ P04150 13/20 1.00
PGR P06401 4/20 1.00
CYP3A4 P08684 4/20 1.00
USP2 O75604 3/20 1.00
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
MMP1 P03956 10/20 0.81
LMNA P02545 2/20 0.75
NR1I2 O75469 2/20 0.75
MAPT P10636 2/20 0.75
MLNR O43193 1/20 0.75
ABCB11 O95342 1/20 0.75
CYP3A5 P20815 1/20 0.75
PPARG P37231 1/20 0.75
SMN1; SMN2 Q16637 1/20 0.75
NPSR1 Q6W5P4 1/20 0.75
CYP2D6 P10635 1/20 0.75
CYP2C9 P11712 1/20 0.75
ADORA3 P0DMS8 1/20 0.74
DRD2 P14416 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betamethasone Valerate SCHEMBL29407278 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL9768484 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL9768470 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL221479 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL16243364 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL11051241 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL14339607 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL7564753 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Betamethasone Valerate SCHEMBL14339612 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1
Dexamethasone Valarate SCHEMBL124723 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4USP2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 18933 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
EP-4744657-A1 THERAPEUTIC AGENT FOR HUMAN GRAFT VERSUS HOST DISEASE AND COMBINATION THEREOF National University Corporation Okayama University (JP) 2026-05-20 EP claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-4724040-A1 TREATMENT OF PSORIASIS TRADOVA (PTY) LTD (ZA) 2026-04-15 EP claimed
EP-3820479-B1 METHODS TO REDUCE COMPLICATIONS OF INTRA-ARTICULAR STEROID TAIWAN LIPOSOME CO LTD (TW) 2026-03-11 EP claimed
EP-4680231-A1 USE OF ORAL JAK KINASE INHIBITORS TO TREAT LICHEN PLANUS Mayo Foundation for Medical Education and Research (US) 2026-01-21 EP claimed
US-12514820-B2 Pharmaceutical composition of intra-articular corticosteroid for pain control TAIWAN LIPOSOME CO., LTD. (TW) 2026-01-06 US claimed
EP-4301343-B1 PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME TLC BIOPHARMACEUTICALS INC (US) 2025-11-19 EP claimed
US-20250332120-A1 COMPOSITION FOR EXTERNAL PREPARATION KAO CORPORATION (JP) 2025-10-30 US claimed
US-20250319104-A1 MOISTURIZING CREAM FOR RADIATION DERMATITIS PERRY ARTHUR W (US) 2025-10-16 US claimed
EP-0050981-A2 Steroid-containing compositions and their topical uses Kumana, Cyrus Rustam (CA) 1982-05-05 EP claimed
US-4304765-A Ocular insert housing steroid in two different therapeutic forms ALZA CORPORATION (US) 1981-12-08 US claimed
EP-0036138-A2 Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide MERCK & CO. INC. (US) 1981-09-23 EP claimed
US-4279900-A ANTIINFLAMMATORY INTREX RESEARCH CORPORATION (US) 1981-07-21 US claimed
US-4250164-A Method of treating psoriasis of the nails and composition BERNSTEIN JOEL E 1981-02-10 US claimed
US-4244942-A Creamy preparation containing steroid and process for the preparation thereof TOKO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) 1981-01-13 US claimed
US-4230621-A TRACERS, HYDROXYPHENYLGLUTARIC ACID DERIVATIVES E. R. SQUIBB & SONS, INC. (US) 1980-10-28 US claimed
US-4130643-A STEROID, SUCROSE ESTER, SULFOXIDE THE PROCTER & GAMBLE COMPANY (US) 1978-12-19 US claimed
US-4083974-A Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether THE UPJOHN COMPANY (US) 1978-04-11 US claimed
US-4070462-A Steroid ointment SCHERING CORPORATION (US) 1978-01-24 US claimed