Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 0.78 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263667 | 0.89 | ACE (0.80) | ACEBRD4NPSR1BRS3AGTR2 | |
| SCHEMBL7263616 | 0.88 | ACE (0.71) | ACEBRD4AGTR2POLBCYP2D6 | |
| SCHEMBL7265312 | 0.82 | ACE (1.00) | ACE | |
| SCHEMBL7270448 | 0.82 | ACE (1.00) | ACE | |
| SCHEMBL11199194 | 0.80 | ACE (0.66) | ACEKMT2A | |
| SCHEMBL11195895 | 0.80 | ACE (0.66) | ACEKMT2A | |
| SCHEMBL11196199 | 0.80 | ACE (0.66) | ACEKMT2A | |
| SCHEMBL7263646 | 0.79 | ACE (1.00) | ACE | |
| SCHEMBL7271330 | 0.79 | ACE (1.00) | ACE | |
| SCHEMBL7270378 | 0.79 | ACE (1.00) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508727-A | Antihypertensive 2-oxo-imidazolidine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1985-04-02 | — | — | US | disclosed |
| EP-0095163-A2 | 2-Oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition | Tanabe Seiyaku Co., Ltd. (JP) | 1983-11-30 | — | — | EP | disclosed |