Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10668874 | 0.86 | ACE (0.51) | ACEITGB1ITGA5ATMITGB3 | |
| SCHEMBL30317311 | 0.85 | ACE (0.57) | ACEITGB1ITGA5ATMITGB3 | |
| SCHEMBL6899829 | 0.85 | ACE (0.57) | ACEITGB1ITGA5ATMITGB3 | |
| SCHEMBL6899827 | 0.85 | ACE (0.57) | ACEITGB1ITGA5ATMITGB3 | |
| SCHEMBL2715722 | 0.80 | ACE (0.56) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL2712732 | 0.80 | ACE (0.56) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL2805870 | 0.80 | ACE (0.56) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL8213582 | 0.77 | ACE (0.53) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL23201306 | 0.76 | ACE (0.53) | ACEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL12935725 | 0.76 | ACE (0.56) | ACEITGB1ITGA5P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | disclosed |