Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 11/20 | 0.66 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.63 |
| ▸ | NOS2 | P35228 | 2/20 | 0.58 |
| ▸ | NOS3 | P29474 | 1/20 | 0.58 |
| ▸ | NOS1 | P29475 | 1/20 | 0.58 |
| ▸ | GSR | P00390 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10683004 | 1.00 | BHMT (0.66) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL7271061 | 1.00 | BHMT (0.66) | BHMTBHMT2NOS2NOS3NOS1 | |
| Cysteamine SCHEMBL11581801 | 0.92 | BHMT (0.58) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL27791649 | 0.91 | BHMT (0.76) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL1031686 | 0.91 | BHMT (0.76) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL1031684 | 0.91 | BHMT (0.76) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL21851894 | 0.91 | BHMT (0.76) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL19800787 | 0.89 | BHMT (0.80) | BHMTBHMT2NOS2NOS3NOS1 | |
| Selenium SCHEMBL30467190 | 0.89 | BHMT (0.73) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL19800783 | 0.89 | BHMT (0.80) | BHMTBHMT2NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0061186-B1 | DIPEPTIDES CONTAINING THIALYSINE AND HOMOLOGS AS ANTIHYPERTENSIVES | MERCK & CO. INC. (US) | 1986-05-21 | — | — | EP | disclosed |
| EP-0073143-B1 | NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES | Ryan, James Walter (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4512979-A | Dipeptides containing thialysine and related amino acids as antihypertensives | MERCK & CO., INC. (US) | 1985-04-23 | — | — | US | disclosed |
| EP-0073143-A2 | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides | Ryan, James Walter (US) | 1983-03-02 | — | — | EP | disclosed |
| EP-0061186-A1 | Dipeptides containing thialysine and homologs as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | disclosed |