Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.91 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.91 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.91 |
| ▸ | MAPT | P10636 | 5/20 | 0.91 |
| ▸ | LMNA | P02545 | 4/20 | 0.91 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.91 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.91 |
| ▸ | TSHR | P16473 | 3/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.91 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.91 |
| ▸ | NPC1 | O15118 | 1/20 | 0.91 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.91 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.91 |
| ▸ | PGR | P06401 | 1/20 | 0.91 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.91 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.91 |
| ▸ | HTR1A | P08908 | 1/20 | 0.91 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.91 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicardipine SCHEMBL6621793 | 0.95 | CYP1A2 (0.97) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL20421321 | 0.95 | CYP1A2 (0.97) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL6621792 | 0.95 | CYP1A2 (0.97) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34277 | 0.95 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL1172950 | 0.95 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL31059901 | 0.95 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL29430153 | 0.95 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34278 | 0.95 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34279 | 0.95 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL1653198 | 0.94 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207514-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1993-09-29 | — | — | EP | disclosed |
| US-4824837-A | VASODILATORS | SUNTORY LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |