Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nicardipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.97 |
| ▸ | MAPT | P10636 | 5/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 3/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.97 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.97 |
| ▸ | NPC1 | O15118 | 1/20 | 0.97 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | PGR | P06401 | 1/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicardipine SCHEMBL6621793 | 1.00 | CYP1A2 (0.97) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL20421321 | 1.00 | CYP1A2 (0.97) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL1172950 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34279 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34278 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL31059901 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL29430153 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34277 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL1653198 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL29465066 | 0.97 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087953-B1 | NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES | NICOX SA (FR) | 2004-11-17 | — | — | EP | disclosed |
| US-20040147575-A1 | Nitrate salts of antihypertensive medicines | NICOX S.A. | 2004-07-29 | — | — | US | disclosed |
| US-6645965-B1 | Sildenafil, hydralazine, minoxidil, or zaprinast; cardiovascular disorders | NICOX S.A. (FR) | 2003-11-11 | — | — | US | disclosed |
| CN-1315945-A | Nitrate salts of antihypertensive drugs | NICOX SA (FR) | 2001-10-03 | — | — | CN | disclosed |
| EP-1087953-A1 | NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES | NICOX S.A. (FR) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999067231-A1 | NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES | NICOX S.A. (FR) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147575-A1 | Nitrate salts of antihypertensive medicines | NOS2, NOS1, NOS3 | CACNA1C 111/4885CYP1A2 255/4885CYP3A4 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.