Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272106 | 0.87 | PDE2A (0.43) | PDE5APDE2ANPC1RAB9AKDM4E | |
| SCHEMBL7272319 | 0.85 | PDE2A (0.42) | PDE5APDE2ANPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7281818 | 0.85 | PDE5A (0.43) | PDE5APDE2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10417545 | 0.84 | PDE5A (0.42) | PDE5APDE2AKDM4EALDH1A1HPGD | |
| SCHEMBL9636108 | 0.82 | PDE2A (0.47) | PDE5APDE2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7270959 | 0.80 | PDE2A (0.58) | PDE5APDE2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10416664 | 0.79 | PDE5A (0.47) | PDE5APDE2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7271892 | 0.79 | PDE5A (0.51) | PDE5APDE2AKDM4EPDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL7272531 | 0.79 | PDE2A (0.57) | PDE5APDE2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7278616 | 0.79 | PDE5A (0.43) | PDE5APDE2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |