Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.51 |
| ▸ | PDE2A | O00408 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9636258 | 0.99 | PDE5A (0.52) | PDE5APDE2APDGFRBPDGFRAPDE3B | |
| SCHEMBL10745905 | 0.88 | AMY1A (0.53) | PDE5APDE2APDGFRBPDGFRAMAPT | |
| Hydrochloric Acid SCHEMBL10737331 | 0.86 | PDGFRB (0.49) | PDE5APDE2APDGFRBPDGFRAPDE3B | |
| SCHEMBL7281375 | 0.86 | PDE5A (0.51) | PDE5APDE2APDE3BPDE3AMAPT | |
| SCHEMBL10964355 | 0.85 | CHEK1 (0.43) | PDE5APDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL7270959 | 0.84 | PDE2A (0.58) | PDE5APDE2APDE3BPDE3AMAPT | |
| SCHEMBL11019408 | 0.83 | AMY1A (0.46) | PDE5APDE2APDGFRBPDGFRAMAPT | |
| SCHEMBL9634292 | 0.83 | PDE5A (0.49) | PDE5APDE2APDE3BPDE3AKDM4E | |
| SCHEMBL11019352 | 0.83 | AMY1A (0.47) | PDE5APDE2APDGFRBPDGFRAMAPT | |
| SCHEMBL11021153 | 0.83 | PDE2A (0.46) | PDE5APDE2APDGFRBPDGFRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0155094-A1 | 2-Arylimidazo(4,5-c)pyridines | ELI LILLY AND COMPANY (US) | 1985-09-18 | — | — | EP | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |