Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 9/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.86 |
| ▸ | PGR | P06401 | 4/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.86 |
| ▸ | TSHR | P16473 | 2/20 | 0.86 |
| ▸ | AR | P10275 | 2/20 | 0.86 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.86 |
| ▸ | MEN1 | O00255 | 2/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | APEX1 | P27695 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.86 |
| ▸ | IKBKB | O14920 | 1/20 | 0.86 |
| ▸ | CHUK | O15111 | 1/20 | 0.86 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.86 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.86 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.86 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexamethasone SCHEMBL124724 | 1.00 | NR3C1 (0.86) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Betamethasone SCHEMBL4888419 | 1.00 | NR3C1 (0.86) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Betamethasone SCHEMBL27837446 | 0.99 | NR3C1 (0.84) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Dexamethasone SCHEMBL25247721 | 0.98 | NR3C1 (0.83) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Betamethasone SCHEMBL20485506 | 0.98 | NR3C1 (0.83) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Dexamethasone SCHEMBL3021335 | 0.98 | NR3C1 (0.83) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Betamethasone SCHEMBL28023838 | 0.98 | NR3C1 (0.83) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Dexamethasone SCHEMBL25253296 | 0.98 | NR3C1 (0.82) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Dexamethasone SCHEMBL25248831 | 0.98 | NR3C1 (0.82) | NR3C1CYP3A4HIF1AHSD17B10PGR | |
| Dexamethasone SCHEMBL25292805 | 0.98 | NR3C1 (0.82) | NR3C1CYP3A4HIF1AHSD17B10PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 17462 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139030-A1 | CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION | SHATTUCK LABS INC (US) | 2026-05-21 | — | — | US | claimed |
| EP-4744657-A1 | THERAPEUTIC AGENT FOR HUMAN GRAFT VERSUS HOST DISEASE AND COMBINATION THEREOF | National University Corporation Okayama University (JP) | 2026-05-20 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4724040-A1 | TREATMENT OF PSORIASIS | TRADOVA (PTY) LTD (ZA) | 2026-04-15 | — | — | EP | claimed |
| EP-3820479-B1 | METHODS TO REDUCE COMPLICATIONS OF INTRA-ARTICULAR STEROID | TAIWAN LIPOSOME CO LTD (TW) | 2026-03-11 | — | — | EP | claimed |
| EP-4680231-A1 | USE OF ORAL JAK KINASE INHIBITORS TO TREAT LICHEN PLANUS | Mayo Foundation for Medical Education and Research (US) | 2026-01-21 | — | — | EP | claimed |
| US-12514820-B2 | Pharmaceutical composition of intra-articular corticosteroid for pain control | TAIWAN LIPOSOME CO., LTD. (TW) | 2026-01-06 | — | — | US | claimed |
| EP-4301343-B1 | PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME | TLC BIOPHARMACEUTICALS INC (US) | 2025-11-19 | — | — | EP | claimed |
| US-20250332120-A1 | COMPOSITION FOR EXTERNAL PREPARATION | KAO CORPORATION (JP) | 2025-10-30 | — | — | US | claimed |
| US-20250319104-A1 | MOISTURIZING CREAM FOR RADIATION DERMATITIS | PERRY ARTHUR W (US) | 2025-10-16 | — | — | US | claimed |
| EP-0068553-A1 | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1983-01-05 | — | — | EP | claimed |
| US-4343798-A | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1982-08-10 | — | — | US | claimed |
| US-4304765-A | Ocular insert housing steroid in two different therapeutic forms | ALZA CORPORATION (US) | 1981-12-08 | — | — | US | claimed |
| EP-0036138-A2 | Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide | MERCK & CO. INC. (US) | 1981-09-23 | — | — | EP | claimed |
| US-4279900-A | ANTIINFLAMMATORY | INTREX RESEARCH CORPORATION (US) | 1981-07-21 | — | — | US | claimed |
| US-4250164-A | Method of treating psoriasis of the nails and composition | BERNSTEIN JOEL E | 1981-02-10 | — | — | US | claimed |
| US-4244942-A | Creamy preparation containing steroid and process for the preparation thereof | TOKO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1981-01-13 | — | — | US | claimed |
| US-4230621-A | TRACERS, HYDROXYPHENYLGLUTARIC ACID DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1980-10-28 | — | — | US | claimed |
| US-4083974-A | Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether | THE UPJOHN COMPANY (US) | 1978-04-11 | — | — | US | claimed |
| US-4070462-A | Steroid ointment | SCHERING CORPORATION (US) | 1978-01-24 | — | — | US | claimed |