Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743722 | 0.85 | HSD11B1 (0.38) | TSHRHSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL22292115 | 0.79 | HSD11B1 (0.34) | TSHRHSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL12254218 | 0.77 | TSHR (0.42) | TSHRHSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL3257641 | 0.77 | TSHR (0.33) | TSHRHSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL9455475 | 0.74 | — | — | |
| SCHEMBL3254927 | 0.74 | FFAR3 (0.32) | TSHRHSD11B1 | |
| SCHEMBL16946087 | 0.72 | HTT (0.32) | TSHRHSD11B1 | |
| SCHEMBL16738685 | 0.70 | CYP2C19 (0.36) | TSHRHSD11B1CYP2C19ALDH1A1 | |
| SCHEMBL16946084 | 0.70 | TSHR (0.31) | TSHRALDH1A1 | |
| SCHEMBL13124944 | 0.70 | AKR1B1 (0.39) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481429-B1 | Quinoline derivatives | SS PHARMACEUTICAL CO (JP) | 2001-01-24 | — | — | EP | disclosed |
| EP-0987262-A1 | Quinoline derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 2000-03-22 | — | — | EP | disclosed |
| US-5300517-A | Treating Alzheimer's | SS PHARMACEUTICAL CO., LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5240934-A | Cognition activators | SS PHARMACEUTICAL CO., LTD. (JP) | 1993-08-31 | — | — | US | disclosed |
| US-5190951-A | Inhibitors of acetylcholinesterase, treatment of senile dementia | SS PHARMACEUTICAL CO., LTD. (JP) | 1993-03-02 | — | — | US | disclosed |
| EP-0481429-A2 | Quinoline derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |