Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.80 |
| ▸ | RAB9A | P51151 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.80 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PYGL | P06737 | 1/20 | 0.44 |
| ▸ | PYGM | P11217 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10485188 | 0.89 | SMN1; SMN2 (0.77) | NPC1RAB9ASMN1; SMN2DDB1CRBN | |
| SCHEMBL30721496 | 0.82 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1MTNR1A | |
| SCHEMBL697728 | 0.82 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1MTNR1A | |
| SCHEMBL3460628 | 0.80 | HTT (0.83) | HTTALDH1A1LMNAKMT2APDE4A | |
| SCHEMBL3459886 | 0.80 | HTT (0.83) | HTTALDH1A1LMNAKMT2APDE4A | |
| SCHEMBL2465110 | 0.80 | HTT (0.83) | HTTALDH1A1LMNAKMT2APDE4A | |
| SCHEMBL29742388 | 0.80 | HTT (0.83) | HTTALDH1A1LMNAKMT2APDE4A | |
| SCHEMBL6634651 | 0.79 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2CRBNALDH1A1 | |
| SCHEMBL695898 | 0.78 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1MTNR1A | |
| SCHEMBL10394613 | 0.78 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420480-A | PARKINSONISM, DEPRESSION, HYPOTENSIVES | MERCK & CO., INC. (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0080115-A2 | Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them | MERCK & CO. INC. (US) | 1983-06-01 | — | — | EP | disclosed |