Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | PDE4A | P27815 | 1/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.61 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | DHODH | Q02127 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459886 | 1.00 | HTT (0.83) | HTTLMNAKMT2APDE4APDE4B | |
| SCHEMBL29742388 | 1.00 | HTT (0.83) | HTTLMNAKMT2APDE4APDE4B | |
| SCHEMBL2465110 | 1.00 | HTT (0.83) | HTTLMNAKMT2APDE4APDE4B | |
| SCHEMBL8160654 | 0.91 | HTT (0.70) | HTTLMNAKMT2APDE4APDE4B | |
| SCHEMBL5436807 | 0.91 | HTT (1.00) | HTTLMNAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL2406255 | 0.91 | HTT (1.00) | HTTLMNAKMT2ATAS1R3TAS1R1 | |
| SCHEMBL7152540 | 0.90 | HTT (0.69) | HTTLMNAKMT2APDE4APDE4B | |
| SCHEMBL7152538 | 0.90 | HTT (0.69) | HTTLMNAKMT2APDE4APDE4B | |
| SCHEMBL6570868 | 0.89 | LMNA (0.69) | HTTLMNAKMT2APDE4APDE4B | |
| SCHEMBL19630401 | 0.88 | HTT (0.66) | HTTLMNAKMT2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | HTT 3606/4885LMNA 3773/4885KMT2A 1273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.