Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | DRD1 | P21728 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10840848 | 1.00 | DRD2 (0.49) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL5998568 | 1.00 | DRD2 (0.49) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL7272577 | 1.00 | DRD2 (0.49) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL4959151 | 1.00 | DRD2 (0.49) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL274433 | 0.89 | DRD2 (0.47) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL9824110 | 0.89 | DRD2 (0.47) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL274434 | 0.89 | DRD2 (0.47) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL31346795 | 0.89 | DRD2 (0.47) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL9824113 | 0.89 | DRD2 (0.47) | DRD2DRD3DRD1LMNAMEN1 | |
| SCHEMBL31346794 | 0.89 | DRD2 (0.47) | DRD2DRD3DRD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0110496-B1 | IMPROVEMENTS IN KETO INTERMEDIATES, THEIR USE AND PREPARATION | ELI LILLY AND COMPANY (US) | 1987-09-02 | — | — | EP | claimed |
| US-4471121-A | Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof | ELI LILLY AND COMPANY (US) | 1984-09-11 | — | — | US | claimed |
| EP-0112604-A1 | Novel resolved keto compounds and process | ELI LILLY AND COMPANY (US) | 1984-07-04 | — | — | EP | claimed |
| JP-4217980-A | — | — | None | — | — | JP | disclosed |
| JP-H04217980-A | PREPARATION OF OCTAHYDROPYRAZOLO(3,4-G)QUINOLINE | ELI LILLY & CO | 1992-08-07 | — | — | JP | disclosed |
| EP-0160502-B1 | Improvements in and relating to octahydrothiazolo[4,5-g]quinolines | ELI LILLY AND COMPANY (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0172697-B1 | Octahydro-oxazolo[4,5-g]quinolines | ELI LILLY AND COMPANY (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0145121-B1 | PYRAZOLOQUINOLINES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1991-08-14 | — | — | EP | disclosed |
| EP-0139393-B1 | PYRIMIDO(4,5-G)QUINOLINES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| EP-0138417-B1 | 2-SUBSTITUTED PYRIMIDOHEXAHYDROQUINOLINES | ELI LILLY AND COMPANY (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4778894-A | TRANS-OCTAHYDROPYRAZOLOQUINOLINES; INTERMEDIATES FOR HYPOTENSIVE AGENTS | ELI LILLY AND COMPANY (US) | 1988-10-18 | — | — | US | disclosed |
| US-4471121-A | Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof | ELI LILLY AND COMPANY (US) | 1984-09-11 | — | — | US | disclosed |
| US-4471121-A | Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof | ELI LILLY AND COMPANY (US) | 1984-09-11 | — | — | US | disclosed |
| US-4468401-A | HYPOTENSIVE AGENT | ELI LILLY AND COMPANY (US) | 1984-08-28 | — | — | US | disclosed |
| EP-0112604-A1 | Novel resolved keto compounds and process | ELI LILLY AND COMPANY (US) | 1984-07-04 | — | — | EP | disclosed |
| EP-0110496-A2 | Improvements in keto intermediates, their use and preparation | ELI LILLY AND COMPANY (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4311844-A | Octahydro-2H-pyrrolo[3,4,-g]quinolines | ELI LILLY AND COMPANY (US) | 1982-01-19 | — | — | US | disclosed |
| US-4282362-A | TREATING PARKINSON'S DISEASE, INHIBITORS OF PRE ACTIN SECRETION, DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4235909-A | DOPAMINE ANTAGONISTS, IN THE TREATMENT OF PARKINSON'S DISEASE | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0013788-A1 | Octahydro-2H-pyrrolo(3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |