SCHEMBL727284

SCHEMBL727284

CCCOc1cc2c(cc1C(C)=O)C(C)(C)CCC2(C)C

nearest known ligand 0.60

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RXRA P19793 17/20 0.60
RXRB P28702 3/20 0.60
RXRG P48443 3/20 0.60
RARA P10276 2/20 0.60
RARB P10826 2/20 0.60
RARG P13631 2/20 0.60
HNF4A P41235 6/20 0.51
CA9 Q16790 1/20 0.49
CYP3A4 P08684 1/20 0.46
TSHR P16473 1/20 0.46
PPARG P37231 1/20 0.44
NR1H3 Q13133 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6916820 0.91 RXRA (0.58) RXRARXRBRXRGRARARARB
SCHEMBL6917792 0.90 RXRA (0.57) RXRARXRBRXRGRARARARB
SCHEMBL6913948 0.90 RXRA (0.57) RXRARXRBRXRGRARARARB
SCHEMBL6909578 0.88 RXRA (0.64) RXRARXRBRXRGRARARARB
SCHEMBL5859918 0.87 RXRA (0.59) RXRARXRBRXRGRARARARB
SCHEMBL6914132 0.85 RXRA (0.54) RXRARXRBRXRGRARARARB
SCHEMBL727908 0.84 RXRA (0.62) RXRARXRBRXRGRARARARB
SCHEMBL6916140 0.82 RXRA (0.61) RXRARXRBRXRGRARARARB
SCHEMBL1140686 0.82 RXRA (0.67) RXRARXRBRXRGRARARARB
SCHEMBL728016 0.82 RXRA (0.67) RXRARXRBRXRGRARARARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4738738-B2 2011-08-03 JP claimed
EP-1576089-A4 EXPANSION OF RENEWABLE STEM CELL POPULATIONS GAMIDA CELL LTD (IL) 2007-02-14 EP claimed
EP-1485464-A4 METHODS OF INDUCING DIFFERENTIATION IN EX VIVO EXPANDED STEM CELLS GAMIDA CELL LTD (IL) 2006-11-29 EP claimed
US-20050220774-A1 Methods of inducing differentiation in ex vivo expanded stem cells GAMIDA CELL LTD. (IL) 2005-10-06 US claimed
JP-2005528088-A 2005-09-22 JP claimed
EP-1576089-A2 EXPANSION OF RENEWABLE STEM CELL POPULATIONS Gamida Cell Ltd. (IL) 2005-09-21 EP claimed
EP-1534820-A2 EX-VIVO EXPANSION OF HEMATOPOIETIC STEM CELL POPULATIONS IN MONONUCLEAR CELL CULTURES Gamida Cell Ltd. (IL) 2005-06-01 EP claimed
US-20050008624-A1 Expansion of renewable stem cell populations GAMIDA CELL LTD. 2005-01-13 US claimed
EP-1485464-A2 METHODS OF INDUCING DIFFERENTIATION IN EX VIVO EXPANDED STEM CELLS Gamida Cell Ltd. (IL) 2004-12-15 EP claimed
WO-2004016731-A2 EX-VIVO EXPANSION OF HEMATOPOIETIC STEM CELL POPULATIONS IN MONONUCLEAR CELL CULTURES GAMIDA-CELL LTD. (IL) 2004-02-26 WO claimed
WO-2003078567-A2 METHODS OF INDUCING DIFFERENTIATION IN EX VIVO EXPANDED STEM CELLS GAMIDA-CELL LTD. (IL) 2003-09-25 WO claimed
WO-2003062369-A2 EXPANSION OF RENEWABLE STEM CELL POPULATIONS GAMIDA-CELL LTD. (IL) 2003-07-31 WO claimed
US-20180320139-A1 EXPANSION OF RENEWABLE STEM CELL POPULATIONS GAMIDA CELL INC. 2018-11-08 US disclosed
US-20160097037-A1 EXPANSION OF RENEWABLE STEM CELL POPULATIONS GAMIDA CELL LTD. 2016-04-07 US disclosed
EP-2206773-B1 Expansion of renewable stem cell populations GAMIDA CELL LTD (IL) 2012-07-11 EP disclosed
US-7955852-B2 Expansion of renewable stem cell populations GAMIDA CELL LTD. (IL) 2011-06-07 US disclosed
WO-2003062369-A2 EXPANSION OF RENEWABLE STEM CELL POPULATIONS GAMIDA-CELL LTD. (IL) 2003-07-31 WO disclosed
US-6545049-B1 E.g., (2E, 4E, 6E)-7-(3,5-diisopropyl-2-n-heptyloxyphenyl)-3-methylocta-2,4,6-trienoic acid, esters or amides thereof LIGAND PHARMACEUTICALS INCORPORATED 2003-04-08 US disclosed
EP-0873295-A1 DIMER-SELECTIVE RXR MODULATORS AND METHODS FOR THEIR USE LIGAND PHARMACEUTICALS, INC. (US) 1998-10-28 EP disclosed
WO-1997012853-A1 DIMER-SELECTIVE RXR MODULATORS AND METHODS FOR THEIR USE LIGAND PHARMACEUTICALS INCORPORATED (US) 1997-04-10 WO disclosed