SCHEMBL7272840

SCHEMBL7272840

CNCc1ccc(Cc2nc3ccccc3[nH]2)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 2/20 0.71
GAA P10253 1/20 0.71
SMN1; SMN2 Q16637 2/20 0.63
GRIN1 Q05586 1/20 0.62
GRIN2B Q13224 1/20 0.62
POLB P06746 2/20 0.58
DDAH1 O94760 1/20 0.56
HDAC3 O15379 1/20 0.55
HDAC4 P56524 1/20 0.55
HDAC1 Q13547 1/20 0.55
HDAC7 Q8WUI4 1/20 0.55
HDAC2 Q92769 1/20 0.55
HDAC10 Q969S8 1/20 0.55
HDAC11 Q96DB2 1/20 0.55
HDAC8 Q9BY41 1/20 0.55
HDAC6 Q9UBN7 1/20 0.55
HDAC9 Q9UKV0 1/20 0.55
HDAC5 Q9UQL6 1/20 0.55
KRAS P01116 1/20 0.55
EGFR P00533 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22356617 0.85 GAA (0.77) PKMGAASMN1; SMN2GRIN1GRIN2B
SCHEMBL29823043 0.85 GAA (0.77) PKMGAASMN1; SMN2GRIN1GRIN2B
SCHEMBL31298007 0.85 PKM (0.96) PKMGAASMN1; SMN2POLBDDAH1
SCHEMBL336412 0.85 PKM (0.96) PKMGAASMN1; SMN2POLBDDAH1
Hydrochloric Acid SCHEMBL30689215 0.83 PKM (1.00) PKMGAASMN1; SMN2POLBDDAH1
Hydrochloric Acid SCHEMBL5205174 0.83 PKM (1.00) PKMGAASMN1; SMN2POLBDDAH1
Hydrochloric Acid SCHEMBL5973175 0.83 PKM (1.00) PKMGAASMN1; SMN2POLBDDAH1
Hydrochloric Acid SCHEMBL27041735 0.83 PKM (1.00) PKMGAASMN1; SMN2POLBDDAH1
Bendazol SCHEMBL29539948 0.83 GAA (1.00) PKMGAASMN1; SMN2GRIN1GRIN2B
Bendazol SCHEMBL309393 0.83 GAA (1.00) PKMGAASMN1; SMN2GRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0268148-B1 TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM F. HOFFMANN-LA ROCHE AG (CH) 1991-12-11 EP disclosed
US-4808605-A Tetrahydronaphthalene derivatives as calcium antagonists HOFFMANN-LA ROCHE INC. (US) 1989-02-28 US disclosed
EP-0268148-A1 Tetrahydronaphthalene derivatives and medicaments containing them F. HOFFMANN-LA ROCHE AG (CH) 1988-05-25 EP disclosed