Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278432 | 0.91 | PDE5A (0.43) | PDE5APDE3BPDE3AKDM4ENPSR1 | |
| SCHEMBL10415609 | 0.90 | PDE5A (0.43) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10417487 | 0.87 | PDE5A (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7271721 | 0.85 | PDE5A (0.53) | PDE5APDE3BPDE3AKDM4ETEK | |
| SCHEMBL9634379 | 0.85 | PDE5A (0.38) | PDE5APDE3BPDE3AKDM4ENPSR1 | |
| SCHEMBL9636120 | 0.85 | PDE5A (0.38) | PDE5AGCGRMAPK14PDE3BPDE3A | |
| SCHEMBL9634482 | 0.85 | PDE5A (0.38) | PDE5APDE3BPDE3AKDM4ENPSR1 | |
| Hydrochloric Acid SCHEMBL9838283 | 0.84 | PDE5A (0.53) | PDE5APDE3BPDE3AKDM4ETEK | |
| Hydrochloric Acid SCHEMBL7277930 | 0.84 | PDE5A (0.53) | PDE5APDE3BPDE3AKDM4ETEK | |
| SCHEMBL7279533 | 0.84 | PDE5A (0.45) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |