Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | RORA | P35398 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | RORB | Q92753 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274898 | 0.86 | TSHR (0.51) | SLC6A2L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL28002722 | 0.85 | CNR2 (0.56) | CNR2PGRRORARORCRORB | |
| SCHEMBL30484777 | 0.85 | CNR2 (0.56) | CNR2PGRRORARORCRORB | |
| SCHEMBL8862370 | 0.85 | CNR2 (0.56) | CNR2PGRRORARORCRORB | |
| SCHEMBL25318908 | 0.85 | CNR2 (0.56) | CNR2PGRRORARORCRORB | |
| SCHEMBL25316072 | 0.85 | CNR2 (0.56) | CNR2PGRRORARORCRORB | |
| SCHEMBL30484776 | 0.85 | CNR2 (0.56) | CNR2PGRRORARORCRORB | |
| SCHEMBL6421284 | 0.84 | CNR2 (0.57) | CNR2PGRRORARORCRORB | |
| SCHEMBL10542753 | 0.83 | CNR2 (0.57) | CNR2L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL7272225 | 0.82 | L3MBTL1 (0.46) | SLC6A2SLC6A4PGRL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4808605-A | Tetrahydronaphthalene derivatives as calcium antagonists | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |