Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273174 | 1.00 | EGFR (0.36) | EGFRRAPGEF3RAPGEF4CYP3A4HPGD | |
| SCHEMBL5069207 | 0.78 | GABRA1 (0.38) | HPGDHSD17B10GABRA1GABRG2GABRB3 | |
| SCHEMBL5069206 | 0.78 | GABRA1 (0.38) | HPGDHSD17B10GABRA1GABRG2GABRB3 | |
| SCHEMBL9238883 | 0.77 | KMT2A (0.34) | ALDH1A1 | |
| SCHEMBL9238889 | 0.77 | KMT2A (0.34) | ALDH1A1 | |
| SCHEMBL5447294 | 0.72 | MEN1 (0.44) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL5447296 | 0.72 | MEN1 (0.44) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL5444465 | 0.69 | MEN1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL22055506 | 0.66 | GAA (0.40) | KDM4EALDH1A1GAA | |
| SCHEMBL14955991 | 0.65 | HPGD (0.43) | RAPGEF4CYP3A4HPGDCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |