Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265452 | 0.98 | POLB (0.73) | POLBPKMHTTDDAH1NPC1 | |
| SCHEMBL7267160 | 0.98 | POLB (0.73) | POLBPKMHTTDDAH1NPC1 | |
| SCHEMBL7275409 | 0.98 | POLB (0.73) | POLBPKMHTTDDAH1NPC1 | |
| SCHEMBL1884521 | 0.95 | POLB (0.72) | POLBPKMHTTDDAH1NPC1 | |
| SCHEMBL2851401 | 0.89 | PKM (0.68) | POLBPKMHTTDDAH1NPC1 | |
| Hydrochloric Acid SCHEMBL8323737 | 0.87 | PKM (0.71) | POLBPKMHTTDDAH1NPC1 | |
| SCHEMBL7006523 | 0.87 | POLB (1.00) | POLBPKMDDAH1NPC1RAB9A | |
| SCHEMBL7034291 | 0.85 | POLB (0.66) | POLBPKMHTTDDAH1NPC1 | |
| SCHEMBL7854826 | 0.85 | POLB (0.96) | POLBPKMDDAH1NPC1RAB9A | |
| SCHEMBL30701864 | 0.85 | POLB (0.96) | POLBPKMDDAH1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4808605-A | Tetrahydronaphthalene derivatives as calcium antagonists | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |