Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12703668 | 0.88 | ALDH1A1 (0.45) | ALDH1A1HIF1AGAAHTTTHRB | |
| SCHEMBL10079669 | 0.84 | GAA (0.48) | ALDH1A1GAAHTTTHRBL3MBTL1 | |
| SCHEMBL10079209 | 0.82 | RECQL (0.51) | GAAHTTMAPTKMT2ALMNA | |
| SCHEMBL14267713 | 0.79 | HSD17B10 (0.49) | ALDH1A1GAAHTTMAPTKMT2A | |
| SCHEMBL6285689 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HIF1AGAAHTTTHRB | |
| SCHEMBL4705081 | 0.78 | HTT (0.53) | ALDH1A1GAAHTTMAPTKMT2A | |
| SCHEMBL24192394 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HTTL3MBTL1MAPTKMT2A | |
| SCHEMBL27603190 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HIF1AGAAHTTTHRB | |
| SCHEMBL6284209 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HIF1AGAAHTTTHRB | |
| SCHEMBL14759747 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HIF1AGAAHTTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4578395-A | Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as antihypertensive | TEIJIN LIMITED (JP) | 1986-03-25 | — | — | US | disclosed |
| EP-0128010-A2 | 1,4-Dihydropyridine derivative, process for production thereof and pharmaceutical use thereof | TEIJIN LIMITED (JP) | 1984-12-12 | — | — | EP | disclosed |