Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.55 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270707 | 1.00 | GRIN2B (0.55) | GRIN2BFUCA1ALDH1A1DRD2KDM1A | |
| SCHEMBL7273877 | 1.00 | GRIN2B (0.55) | GRIN2BFUCA1ALDH1A1DRD2KDM1A | |
| Hydrochloric Acid SCHEMBL11803518 | 0.98 | GRIN2B (0.54) | GRIN2BFUCA1ALDH1A1DRD2KDM1A | |
| SCHEMBL12362863 | 0.84 | FUCA1 (0.48) | GRIN2BFUCA1DRD2KDM1AMAOA | |
| SCHEMBL15613459 | 0.81 | HTR1A (0.47) | DRD2MAOA | |
| Hydrochloric Acid SCHEMBL9854742 | 0.79 | GRIN2B (0.53) | GRIN2BKDM1AMAOA | |
| SCHEMBL7426273 | 0.78 | HTR1A (0.68) | MAOA | |
| SCHEMBL7149968 | 0.78 | GRIN2B (0.62) | GRIN2BALDH1A1KDM1AMAOAKDM4E | |
| SCHEMBL2160788 | 0.78 | GRIN2B (0.62) | GRIN2BALDH1A1KDM1AMAOAKDM4E | |
| SCHEMBL7146949 | 0.78 | GRIN2B (0.62) | GRIN2BALDH1A1KDM1AMAOAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420480-A | PARKINSONISM, DEPRESSION, HYPOTENSIVES | MERCK & CO., INC. (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0080115-A2 | Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them | MERCK & CO. INC. (US) | 1983-06-01 | — | — | EP | disclosed |