Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274738 | 0.90 | ACHE (0.41) | ACHEBCHEALDH1A1LMNAMAPT | |
| SCHEMBL7274740 | 0.90 | ACHE (0.41) | ACHEBCHEALDH1A1LMNAMAPT | |
| SCHEMBL7281630 | 0.88 | ACHE (0.40) | ACHEALDH1A1LMNAMAPTHTT | |
| SCHEMBL7281624 | 0.88 | ACHE (0.40) | ACHEALDH1A1LMNAMAPTHTT | |
| SCHEMBL7272877 | 0.87 | KDM4E (0.41) | ACHEBCHEALDH1A1LMNAMAPT | |
| SCHEMBL7272871 | 0.87 | KDM4E (0.41) | ACHEBCHEALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL7282884 | 0.83 | MEN1 (0.47) | ACHEALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL7282887 | 0.83 | MEN1 (0.47) | ACHEALDH1A1LMNAMAPT | |
| SCHEMBL7284054 | 0.82 | ACHE (0.40) | ACHEALDH1A1MAPK1 | |
| SCHEMBL7272068 | 0.82 | ACHE (0.41) | ACHEBCHEALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481429-B1 | Quinoline derivatives | SS PHARMACEUTICAL CO (JP) | 2001-01-24 | — | — | EP | disclosed |
| EP-0987262-A1 | Quinoline derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 2000-03-22 | — | — | EP | disclosed |
| US-5300517-A | Treating Alzheimer's | SS PHARMACEUTICAL CO., LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5240934-A | Cognition activators | SS PHARMACEUTICAL CO., LTD. (JP) | 1993-08-31 | — | — | US | disclosed |
| US-5190951-A | Inhibitors of acetylcholinesterase, treatment of senile dementia | SS PHARMACEUTICAL CO., LTD. (JP) | 1993-03-02 | — | — | US | disclosed |
| EP-0481429-A2 | Quinoline derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |