Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 14/20 | 0.49 |
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276615 | 0.88 | NPC1 (0.49) | ELANECTRCNPC1RAB9AMAOB | |
| SCHEMBL7276630 | 0.86 | ELANE (0.50) | ELANECTRCNPC1RAB9AMAOB | |
| SCHEMBL7229401 | 0.83 | ELANE (0.60) | ELANECTRCNPC1RAB9AMAOB | |
| SCHEMBL7276489 | 0.80 | ELANE (0.69) | ELANECTRCNPC1RAB9A | |
| SCHEMBL4214512 | 0.78 | NPC1 (0.44) | ELANECTRCNPC1RAB9AMAOB | |
| SCHEMBL4424252 | 0.78 | ELANE (0.61) | ELANECTRCNPC1RAB9ACASP1 | |
| SCHEMBL6556136 | 0.76 | ELANE (0.62) | ELANECTRCNPC1RAB9A | |
| SCHEMBL21685581 | 0.76 | ELANE (0.49) | ELANECTRCNPC1RAB9ACASP1 | |
| SCHEMBL9011620 | 0.76 | ELANE (0.49) | ELANECTRC | |
| SCHEMBL7275624 | 0.76 | ELANE (0.51) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |