Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 16/20 | 0.62 |
| ▸ | CTRC | Q99895 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274862 | 0.92 | ELANE (0.68) | ELANECTRCNPC1RAB9A | |
| SCHEMBL6556073 | 0.88 | ELANE (0.65) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7276615 | 0.88 | NPC1 (0.49) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7444479 | 0.83 | ELANE (0.60) | ELANENPC1RAB9ACYP2C9CYP2C19 | |
| SCHEMBL7276556 | 0.82 | ELANE (0.58) | ELANECTRCNPC1RAB9AL3MBTL1 | |
| SCHEMBL7276489 | 0.80 | ELANE (0.69) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7276380 | 0.79 | ELANE (0.73) | ELANECTRCNPC1RAB9A | |
| SCHEMBL6556063 | 0.78 | ELANE (0.79) | ELANECTRC | |
| SCHEMBL7274723 | 0.78 | ELANE (0.73) | ELANECTRC | |
| SCHEMBL6556283 | 0.78 | ELANE (0.70) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188401-C | Heterocyclic amide compound and its pharmaceutical use | MITSUBISHI PHARMACEUTICAL CO L (JP) | 2005-02-09 | — | — | CN | disclosed |
| EP-0826671-B1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2004-12-29 | — | — | EP | disclosed |
| CN-1131210-C | Heterocyclic amide compound and medical use thereof | MITSUBISHI SEIYAKU CO LTD (JP) | 2003-12-17 | — | — | CN | disclosed |
| CN-1304931-A | Heterocyclic amide compound and medical use thereof | EFUKU CO LTD (JP) | 2001-07-25 | — | — | CN | disclosed |
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |
| CN-1188472-A | Heterocyclic amide compound and medical use thereof | GREEN CROSS CORP (JP) | 1998-07-22 | — | — | CN | disclosed |
| EP-0826671-A1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | THE GREEN CROSS CORPORATION (JP) | 1998-03-04 | — | — | EP | disclosed |
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |