Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656443 | 0.92 | CYP3A4 (0.79) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| Hydrochloric Acid SCHEMBL9148260 | 0.91 | BLM (0.79) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL10637079 | 0.88 | CYP3A4 (0.77) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL10733622 | 0.87 | CYP3A4 (0.74) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL6575808 | 0.83 | CYP3A4 (0.84) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL18239557 | 0.83 | CYP3A4 (0.90) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL7430428 | 0.82 | CYP1A2 (1.00) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL10338948 | 0.81 | CYP3A4 (0.74) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL7266640 | 0.81 | CYP3A4 (0.79) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL7266646 | 0.81 | CYP3A4 (0.79) | CYP3A4CYP1A2CYP2D6BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302793-B1 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | disclosed |
| US-5215988-A | Treating angina, hypertension, arrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-06-01 | — | — | US | disclosed |
| US-5182291-A | Angina pectoris, hypotensive, antiarrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5039700-A | Cardiovascular disorders, antitumor agents | SANOFI (FR) | 1991-08-13 | — | — | US | disclosed |
| US-5028710-A | Oxidation of corresponding 3-phenylthio indolizine | SANOFI (FR) | 1991-07-02 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4994474-A | Hypotensive agents | SANOFI (FR) | 1991-02-19 | — | — | US | disclosed |
| US-4957925-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA | SANOFI (FR) | 1990-09-18 | — | — | US | disclosed |
| EP-0302793-A2 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | ELF SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |