Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | NR1D1 | P20393 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27431282 | 1.00 | ACE (0.62) | ACEPOLBABCB11NR1D1TDP1 | |
| SCHEMBL7274651 | 1.00 | ACE (0.62) | ACEPOLBABCB11NR1D1TDP1 | |
| SCHEMBL28556786 | 0.89 | NR1D1 (0.68) | ACEPOLBABCB11NR1D1NPSR1 | |
| SCHEMBL29409301 | 0.89 | NR1D1 (0.68) | ACEPOLBABCB11NR1D1NPSR1 | |
| SCHEMBL27580687 | 0.88 | ACE (0.56) | ACEPOLBABCB11NR1D1TDP1 | |
| SCHEMBL27580689 | 0.88 | ACE (0.56) | ACEPOLBABCB11NR1D1TDP1 | |
| SCHEMBL1052393 | 0.86 | NPSR1 (0.62) | ACEPOLBABCB11TDP1L3MBTL1 | |
| SCHEMBL29401156 | 0.86 | NPSR1 (0.62) | ACEPOLBABCB11TDP1L3MBTL1 | |
| SCHEMBL30314166 | 0.86 | NPSR1 (0.62) | ACEPOLBABCB11TDP1L3MBTL1 | |
| SCHEMBL14862925 | 0.86 | NPSR1 (0.62) | ACEPOLBABCB11TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4680284-A | RENNIN INHIBITORS, HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |