Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15435555 | 0.85 | RECQL (0.52) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL25434321 | 0.78 | RECQL (0.55) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL17603200 | 0.78 | RECQL (0.55) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL7234130 | 0.77 | RAD52 (0.56) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL15804012 | 0.77 | RECQL (0.51) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL26181571 | 0.76 | RECQL (0.42) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL16794652 | 0.75 | RECQL (0.52) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL20945118 | 0.75 | RECQL (0.52) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL13075102 | 0.74 | ALDH1A1 (0.51) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL15804039 | 0.74 | RECQL (0.51) | RECQLALDH1A1HTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |