SCHEMBL7274701

SCHEMBL7274701

CS(=O)(=O)OCCCCC(=O)O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.65
ALDH1A1 P00352 4/20 0.65
LMNA P02545 3/20 0.65
ALOX15 P16050 2/20 0.65
KDM4E B2RXH2 1/20 0.65
USP2 O75604 1/20 0.65
MMP9 P14780 1/20 0.65
NFKB1 P19838 1/20 0.46
PMP22 Q01453 1/20 0.46
AKR1B1 P15121 1/20 0.44
FNTA P49354 1/20 0.43
FNTB P49356 1/20 0.43
GPR84 Q9NQS5 7/20 0.43
PPARG P37231 7/20 0.43
PPARD Q03181 7/20 0.43
PPARA Q07869 7/20 0.43
HDAC11 Q96DB2 5/20 0.43
PTPN1 P18031 3/20 0.43
TLR2 O60603 2/20 0.43
TDP1 Q9NUW8 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9828620 0.98 TSHR (0.62) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL27585479 0.98 TSHR (0.62) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL8612177 0.98 TSHR (0.62) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL8863774 0.98 TSHR (0.62) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL18704280 0.98 TSHR (0.62) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL4745492 0.93 TSHR (0.61) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL18095432 0.92 TSHR (0.56) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL11343814 0.84 ALDH1A1 (0.68) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL27788663 0.84 ALDH1A1 (0.68) TSHRALDH1A1LMNAALOX15KDM4E
SCHEMBL14151795 0.84 TSHR (0.56) TSHRALDH1A1LMNAALOX15KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3773573-A1 ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) Morphic Therapeutic, Inc. (US) 2021-02-17 EP disclosed
WO-2019200202-A1 ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) MORPHIC THERAPEUTIC, INC. (US) 2019-10-17 WO disclosed
EP-2739625-A1 CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS Bristol-Myers Squibb Company (US) 2014-06-11 EP disclosed
WO-2013022814-A1 CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2013-02-14 WO disclosed
EP-0758328-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BTG INTERNATIONAL LIMITED (GB) 1997-02-19 EP disclosed
WO-1995030673-A1 ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING BRITISH TECHNOLOGY GROUP LIMITED (GB) 1995-11-16 WO disclosed
EP-0222413-B1 NOVEL FORSKOLIN DERIVATIVES NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1992-02-05 EP disclosed
US-4954642-A INOTROPIC, HYPOTENSIVE NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-09-04 US disclosed
EP-0271287-A2 Quinoline dioic acids and amides MERCK FROSST CANADA INC. (CA) 1988-06-15 EP disclosed
EP-0222413-A2 Novel forskolin derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1987-05-20 EP disclosed