Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.50 |
| ▸ | CTSL | P07711 | 5/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | CTSB | P07858 | 4/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275098 | 1.00 | CTSK (0.50) | CTSKCTSLCTSSCTSBPSMB1 | |
| SCHEMBL7275090 | 1.00 | CTSK (0.50) | CTSKCTSLCTSSCTSBPSMB1 | |
| SCHEMBL4678519 | 0.88 | CTSK (0.53) | CTSKCTSLCTSSCTSBATM | |
| SCHEMBL602597 | 0.83 | ATM (0.56) | CTSKCTSLCTSSCTSBATM | |
| SCHEMBL6356795 | 0.81 | CTSK (0.51) | CTSKCTSLCTSSCTSBATM | |
| SCHEMBL7270342 | 0.81 | CA1 (0.43) | CTSKCTSLCTSSCTSBREN | |
| SCHEMBL7270348 | 0.81 | CA1 (0.43) | CTSKCTSLCTSSCTSBREN | |
| SCHEMBL8353955 | 0.80 | CTSK (0.62) | CTSKCTSLCTSSCTSBPSMB1 | |
| SCHEMBL14011286 | 0.78 | CTSK (0.64) | CTSKCTSLCTSSCTSBATM | |
| SCHEMBL7292473 | 0.78 | CTSK (0.60) | CTSKCTSLCTSSCTSBPSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106835-A | Hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |
| EP-0376012-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |