Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 14/20 | 0.45 |
| ▸ | PYGM | P11217 | 14/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265805 | 0.94 | MEN1 (0.68) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| SCHEMBL49022 | 0.87 | ADORA3 (0.76) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| SCHEMBL5206556 | 0.87 | ADORA3 (0.75) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| Water SCHEMBL7274859 | 0.82 | PDE4D (0.73) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| Water SCHEMBL7267002 | 0.81 | MEN1 (0.72) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| SCHEMBL7272814 | 0.81 | ADORA3 (1.00) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| Azelnidipine SCHEMBL49021 | 0.81 | ADORA3 (1.00) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| Azelnidipine SCHEMBL3092194 | 0.81 | ADORA3 (1.00) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| Azelnidipine SCHEMBL3098831 | 0.81 | ADORA3 (1.00) | MEN1MLNRNR1I2ADRB1ADORA3 | |
| Azelnidipine SCHEMBL29349688 | 0.81 | ADORA3 (1.00) | MEN1MLNRNR1I2ADRB1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529702-B1 | Dihydropyridine derivatives, their preparation and their use | SANKYO CO (JP) | 1996-12-11 | — | — | EP | disclosed |
| EP-0529702-A1 | Dihydropyridine derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-4772596-A | CALCIUM BLOCKERS | SANKYO COMPANY LIMITED (JP) | 1988-09-20 | — | — | US | disclosed |
| EP-0266922-A1 | Dihydropyridine derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-05-11 | — | — | EP | disclosed |