Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | USP14 | P54578 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282605 | 0.89 | CYP11B1 (0.50) | CYP11B1CYP11B2ALDH1A1MAPTCYP3A4 | |
| Hydrochloric Acid SCHEMBL8571479 | 0.88 | CYP11B1 (0.49) | CYP11B1CYP11B2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL7281169 | 0.85 | CYP11B1 (0.48) | CYP11B1CYP11B2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL1338556 | 0.83 | CYP11B1 (0.60) | CYP11B1CYP11B2ALDH1A1MAPTHTT | |
| SCHEMBL7272668 | 0.82 | CYP11B1 (0.46) | CYP11B1CYP11B2ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL9138661 | 0.81 | CYP11B1 (0.49) | CYP11B1CYP11B2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL7282052 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL3628694 | 0.79 | CYP11B1 (0.56) | CYP11B1CYP11B2ALDH1A1MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL8573704 | 0.79 | ITGB3 (0.52) | HRH3 | |
| SCHEMBL7282157 | 0.79 | CYP11B1 (0.41) | CYP11B1CYP11B2ALDH1A1MAPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |