Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.50 |
| ▸ | PDE4A | P27815 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11634250 | 0.83 | PDE3B (0.50) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9184755 | 0.82 | PDE3B (0.57) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7276255 | 0.79 | PDE3B (0.46) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL11738657 | 0.77 | PDE3B (0.55) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10755676 | 0.77 | PDE3B (0.58) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL11006840 | 0.76 | SMN1; SMN2 (0.62) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10961174 | 0.75 | PDE3B (0.54) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7275119 | 0.75 | GALR3 (0.60) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL10353452 | 0.75 | SMN1; SMN2 (0.81) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL7273699 | 0.75 | PDE3B (0.54) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326307-B1 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO KK (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5063227-A | QUINAZOLINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES HAVING CARDIOTONIC ACTIVITY | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| EP-0326307-A2 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |