Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8951498 | 1.00 | TDP1 (0.49) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL7276340 | 1.00 | TDP1 (0.49) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8555666 | 0.78 | TDP1 (0.49) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8552133 | 0.76 | ALDH1A1 (0.56) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8552131 | 0.76 | ALDH1A1 (0.56) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8860083 | 0.72 | ALDH1A1 (0.51) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8860080 | 0.72 | ALDH1A1 (0.51) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL14866021 | 0.72 | TDP1 (0.58) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8799111 | 0.71 | TDP1 (0.54) | TDP1ALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL8799115 | 0.71 | TDP1 (0.54) | TDP1ALDH1A1GAAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580999-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-12-03 | — | — | US | disclosed |
| US-5571920-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0432694-B1 | Aminoalcohols | HOFFMANN LA ROCHE (CH) | 1996-05-29 | — | — | EP | disclosed |
| US-5516913-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5508430-A | Oxirane intermediates for novel alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5488115-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451678-A | Intermediates for viricides | HOFFMANN-LA ROCHE INC. (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0657419-A1 | Alcohols | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |
| EP-0432694-A2 | Aminoalcohols | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-19 | — | — | EP | disclosed |