Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 18/20 | 0.73 |
| ▸ | CTRC | Q99895 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276489 | 0.91 | ELANE (0.69) | ELANECTRCNPC1RAB9A | |
| SCHEMBL6556073 | 0.88 | ELANE (0.65) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7285628 | 0.85 | ELANE (1.00) | ELANECTRC | |
| SCHEMBL7282876 | 0.84 | ELANE (0.79) | ELANECTRC | |
| SCHEMBL6556136 | 0.79 | ELANE (0.62) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7276788 | 0.78 | ELANE (1.00) | ELANECTRC | |
| SCHEMBL7283179 | 0.77 | ELANE (0.77) | ELANECTRC | |
| SCHEMBL7276630 | 0.75 | ELANE (0.50) | ELANECTRCNPC1RAB9ACASP1 | |
| SCHEMBL7276304 | 0.74 | ELANE (0.70) | ELANECTRC | |
| SCHEMBL7283877 | 0.74 | ELANE (1.00) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |