Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | GALR3 | O60755 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333497 | 0.89 | PDE3B (0.55) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL2015885 | 0.82 | GALR3 (0.74) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL7267599 | 0.82 | MAPT (0.48) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL10704549 | 0.80 | PDE3B (0.51) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL10962981 | 0.79 | MAPT (0.46) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL7268573 | 0.79 | MAPT (0.65) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL10704095 | 0.79 | PDE3B (0.51) | MAPTGALR3THRBPDE3BPDE3A | |
| SCHEMBL11013347 | 0.78 | PDE3B (0.45) | MAPTSMN1; SMN2PDE3BPDE3AGAA | |
| SCHEMBL7273714 | 0.75 | MAPT (0.56) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL7352543 | 0.75 | MAPT (0.73) | MAPTGALR3SMN1; SMN2THRBPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327800-B1 | 6-PHENYLDIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | HEUMANN PHARMA GMBH & CO (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0327800-A2 | 6-Phenyldihydro-3(2H)-pyridazinones, process for their preparation and medicines containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1989-08-16 | — | — | EP | disclosed |