Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | GALR3 | O60755 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | KAT2B | Q92831 | 7/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273931 | 0.87 | GALR3 (0.79) | MAPTGALR3SMN1; SMN2KAT2BTHRB | |
| SCHEMBL7267555 | 0.81 | GALR3 (0.81) | MAPTGALR3SMN1; SMN2KAT2BTHRB | |
| SCHEMBL7266722 | 0.79 | MAPT (0.51) | MAPTGALR3SMN1; SMN2THRBDHFR | |
| SCHEMBL7299089 | 0.79 | MAPT (0.51) | MAPTGALR3SMN1; SMN2THRBDHFR | |
| SCHEMBL7276392 | 0.79 | MAPT (0.53) | MAPTGALR3SMN1; SMN2THRBDHFR | |
| SCHEMBL16157214 | 0.79 | MAPT (1.00) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL7299102 | 0.78 | MAPT (0.48) | MAPTGALR3SMN1; SMN2THRBDHFR | |
| SCHEMBL9729253 | 0.77 | MAPT (0.54) | MAPTGALR3SMN1; SMN2KAT2BTHRB | |
| SCHEMBL10475489 | 0.76 | MAPT (0.74) | MAPTGALR3SMN1; SMN2THRBPDE3B | |
| SCHEMBL10474001 | 0.76 | GALR3 (0.76) | MAPTGALR3SMN1; SMN2THRBPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339208-B1 | 6-Oxopyridazine derivatives, process for their preparation and medicaments containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1996-02-07 | — | — | EP | disclosed |
| EP-0327800-B1 | 6-PHENYLDIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | HEUMANN PHARMA GMBH & CO (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4968683-A | INOTROPIC, CARDIOTONIC | HEUMANN PHARMA GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0339208-A1 | 6-Oxopyridazine derivatives, process for their preparation and medicaments containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1989-11-02 | — | — | EP | disclosed |
| EP-0327800-A2 | 6-Phenyldihydro-3(2H)-pyridazinones, process for their preparation and medicines containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1989-08-16 | — | — | EP | disclosed |