Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 17/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.57 |
| ▸ | PDE5A | O76074 | 15/20 | 0.46 |
| ▸ | PDE1A | P54750 | 14/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 14/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 14/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286296 | 0.87 | PDE3B (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7276791 | 0.85 | PDE3B (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL3883045 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7285560 | 0.80 | PDE3B (0.52) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7279466 | 0.79 | PDE3B (0.49) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7746636 | 0.79 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7747600 | 0.79 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL3880895 | 0.79 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7286791 | 0.77 | PDE3B (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7749441 | 0.77 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557016-B1 | Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor | TANABE SEIYAKU CO (JP) | 1996-06-19 | — | — | EP | disclosed |
| US-5342941-A | Bronchodilating agents | TANABE SEIYAKU CO., LTD. (JP) | 1994-08-30 | — | — | US | disclosed |
| EP-0557016-A1 | Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor | TANABE SEIYAKU CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |