Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.48 |
| ▸ | PDE5A | O76074 | 10/20 | 0.41 |
| ▸ | PDE1A | P54750 | 10/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 10/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 10/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286296 | 0.89 | PDE3B (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7747490 | 0.85 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7278598 | 0.79 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7276796 | 0.79 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7749398 | 0.78 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7276791 | 0.74 | PDE3B (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL3880895 | 0.74 | PDE3B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7278959 | 0.73 | PDE1A (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL3883045 | 0.72 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL27398805 | 0.71 | MTNR1A (0.43) | ALDH1A1HSD17B10HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214996-B1 | SHOWING EXCELLENT BRONCHIOCONSTRICTION INHIBITORY ACTIVITY,USEFUL IN THE PROPHYLAXIS OR TREATNEBT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| US-6005106-A | BRONCHOCONSTRICTOR AGENTS USEFUL IN THE TREATMENT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 1999-12-21 | — | — | US | disclosed |
| US-5969140-A | AMINOPYRIDINE DERIVATIVES OF NAPHTHALENE FOR TREATMENT OF ASTHMA AND BRONCHOCONSTRICTOR INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0748805-B1 | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor, and pharmaceutical compositions comprising them | TANABE SEIYAKU CO (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0748805-A1 | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor, and pharmaceutical compositions comprising them | TANABE SEIYAKU CO., LTD. (JP) | 1996-12-18 | — | — | EP | disclosed |