Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269210 | 1.00 | NPC1 (0.50) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL7284168 | 1.00 | NPC1 (0.50) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL6002636 | 0.94 | NPC1 (0.49) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL2850953 | 0.93 | NPC1 (0.48) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL28938264 | 0.93 | NPC1 (0.48) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL5834937 | 0.90 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL14386089 | 0.90 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL12235253 | 0.90 | NPC1 (0.51) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL920229 | 0.89 | NPC1 (0.50) | NPC1RAB9AKMT2AHTR1ATSHR | |
| SCHEMBL4440609 | 0.86 | NPC1 (0.57) | NPC1RAB9AKMT2AHTR1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |
| EP-0376012-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |
| US-4524123-A | POLYETHERSILOXANE COPOLYMERS, HIGH MOLECULAR WEIGHT POLYETHYLEN, AND EMULSIFIER | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1985-06-18 | — | — | US | disclosed |