Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.66 |
| ▸ | HTR3B | O95264 | 2/20 | 0.66 |
| ▸ | HTR3A | P46098 | 2/20 | 0.66 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.66 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11293482 | 0.98 | HTR3E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1350643 | 0.90 | HTR3E (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1350641 | 0.90 | HTR3E (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2131162 | 0.84 | HTR3E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL17151386 | 0.81 | HTR3E (0.56) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL24126286 | 0.80 | HTR3E (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL12093611 | 0.80 | HTR3E (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL14018541 | 0.80 | HTR3E (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30422638 | 0.80 | HTR3E (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL31381324 | 0.80 | TDP1 (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506545-B1 | Use of 4-amino-1-(2-pyridyl)piperidines as 5-HT3-agonists for the treatment and prophylaxis of serotoninergic dysfunctions | SANOFI SA (FR) | 1998-12-30 | — | — | EP | claimed |
| US-5604245-A | Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a medicament for the treatment of conditions deriving from disorders of the serotoninergic systems mediated by 5-HT3 receptors | ELF SANOFI (FR) | 1997-02-18 | — | — | US | claimed |
| EP-0535626-A1 | Use of 4-amino-1-(2-pyridyl)piperidines as anti-convulsivant and anti-epileptic agents | SANOFI (FR) | 1993-04-07 | — | — | EP | claimed |
| EP-0506545-A2 | Use of 4-amino-1-(2-pyridyl)piperidines as 5-HT3-agonists for the treatment and prophylaxis of serotoninergic dysfunctions | SANOFI (FR) | 1992-09-30 | — | — | EP | claimed |
| EP-0021973-B1 | ANORECTIC AMINO PIPERIDINES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SANOFI S.A. (FR) | 1982-12-08 | — | — | EP | claimed |
| EP-3646886-B1 | TREATMENT OF PAIN WITH SEROTONIN-3 RECEPTOR AGONIST | UNIV OSAKA (JP) | 2023-10-04 | — | — | EP | disclosed |
| EP-0506545-B1 | Use of 4-amino-1-(2-pyridyl)piperidines as 5-HT3-agonists for the treatment and prophylaxis of serotoninergic dysfunctions | SANOFI SA (FR) | 1998-12-30 | — | — | EP | disclosed |
| US-5604245-A | Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a medicament for the treatment of conditions deriving from disorders of the serotoninergic systems mediated by 5-HT3 receptors | ELF SANOFI (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0535626-A1 | Use of 4-amino-1-(2-pyridyl)piperidines as anti-convulsivant and anti-epileptic agents | SANOFI (FR) | 1993-04-07 | — | — | EP | disclosed |
| EP-0506545-A2 | Use of 4-amino-1-(2-pyridyl)piperidines as 5-HT3-agonists for the treatment and prophylaxis of serotoninergic dysfunctions | SANOFI (FR) | 1992-09-30 | — | — | EP | disclosed |
| US-4409228-A | ANOREXIGENIC AGENTS | SANOFI (FR) | 1983-10-11 | — | — | US | disclosed |
| EP-0021973-B1 | ANORECTIC AMINO PIPERIDINES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SANOFI S.A. (FR) | 1982-12-08 | — | — | EP | disclosed |
| EP-0045980-A1 | Compounds useful in the preparation of aminopiperidines with anorectic properties | SANOFI S.A. (FR) | 1982-02-17 | — | — | EP | disclosed |
| EP-0021973-A2 | Anorectic amino piperidines, process for their preparation and medicaments containing them | SANOFI S.A. (FR) | 1981-01-07 | — | — | EP | disclosed |