SCHEMBL7277005

SCHEMBL7277005

CC(C)C(NC(=O)Cn1c(-c2ccccc2Cl)ccc(NC(=O)OCc2ccccc2)c1=O)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 0.69
CTRC Q99895 5/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7276661 0.91 ELANE (0.67) ELANECTRC
SCHEMBL7276644 0.87 ELANE (0.76) ELANECTRC
SCHEMBL7279603 0.87 ELANE (0.69) ELANECTRC
SCHEMBL7274647 0.87 ELANE (0.70) ELANECTRC
SCHEMBL7277022 0.86 ELANE (0.61) ELANECTRC
SCHEMBL7283926 0.85 ELANE (0.62) ELANECTRC
SCHEMBL7281272 0.85 ELANE (0.58) ELANECTRC
SCHEMBL7285204 0.83 ELANE (0.53) ELANECTRC
SCHEMBL7292100 0.82 ELANE (0.65) ELANECTRC
SCHEMBL9584647 0.82 ELANE (0.70) ELANECTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578247-A OXIDATION POLYMERIZATION OF THIOPHENE, ANILINE OR PYRROLE ADDITIVE THREE BOND CO., LTD. (JP) 1996-11-26 US disclosed
US-5521179-A Heterocyclic amides ZENECA LIMITED (GB) 1996-05-28 US disclosed
US-5462696-A Cured thermosetting resin containing one or more of an oxidizable aniline, thiophene or pyrrole additive THREE BOND COMPANY, LTD. (JP) 1995-10-31 US disclosed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 EP disclosed