Sugi Predict

Sugi Predict / Compounds / SCHEMBL7285204

SCHEMBL7285204

SCHEMBL7285204

Cc1c(-c2ccccc2)cc(NC(=O)OCc2ccccc2)c(=O)n1CC(=O)NC(C(C)C)C(O[Si](C)(C)C(C)(C)C)C(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 20/20 0.53
▸ CTRC Q99895 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9584647 0.88 ELANE (0.70) ELANECTRC
SCHEMBL7276661 0.88 ELANE (0.67) ELANECTRC
SCHEMBL7276849 0.86 ELANE (0.56) ELANECTRC
SCHEMBL9584444 0.84 ELANE (0.71) ELANECTRC
SCHEMBL9584359 0.84 ELANE (0.64) ELANE
SCHEMBL7274647 0.84 ELANE (0.70) ELANECTRC
SCHEMBL7283926 0.84 ELANE (0.62) ELANECTRC
SCHEMBL7277005 0.83 ELANE (0.69) ELANECTRC
SCHEMBL7275613 0.83 ELANE (0.55) ELANECTRC
SCHEMBL7274260 0.83 ELANE (0.67) ELANECTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521179-A Heterocyclic amides ZENECA LIMITED (GB) 1996-05-28 — — US disclosed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 — — EP disclosed