Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294011 | 0.92 | EPHX1 (0.56) | EPHX1CYP2D6CYP2C19CA1CNR1 | |
| SCHEMBL9462565 | 0.88 | MAPK1 (0.49) | EPHX1CYP2D6CYP2C19CA1CA2 | |
| SCHEMBL26859064 | 0.84 | CYP2D6 (0.45) | EPHX1CYP2D6CYP2C19CA1CNR1 | |
| SCHEMBL22020057 | 0.83 | CA1 (0.47) | CA1CNR1DPP7SLC15A1CA2 | |
| SCHEMBL24380598 | 0.82 | DPP7 (0.56) | EPHX1CA1CNR1DPP7MMP8 | |
| SCHEMBL9462535 | 0.82 | DPP7 (0.52) | EPHX1CA1CNR1DPP7SLC15A1 | |
| SCHEMBL25086839 | 0.82 | CYP2D6 (0.46) | EPHX1CYP2D6CYP2C19MMP1MMP8 | |
| SCHEMBL5224064 | 0.81 | DPP7 (0.66) | EPHX1CYP2D6CYP2C19DPP7SLC15A1 | |
| SCHEMBL27789284 | 0.81 | DPP7 (0.66) | EPHX1CYP2D6CYP2C19DPP7SLC15A1 | |
| SCHEMBL21467378 | 0.80 | DPP7 (0.65) | EPHX1CA1CNR1DPP7MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383635-B1 | Peptides having renin inhibitory activity their preparation and use | SANKYO CO (JP) | 1995-07-12 | — | — | EP | claimed |
| EP-0383635-A2 | Peptides having renin inhibitory activity their preparation and use | Sankyo Company Limited (JP) | 1990-08-22 | — | — | EP | claimed |
| EP-0383635-B1 | Peptides having renin inhibitory activity their preparation and use | SANKYO CO (JP) | 1995-07-12 | — | — | EP | disclosed |
| EP-0383635-A2 | Peptides having renin inhibitory activity their preparation and use | Sankyo Company Limited (JP) | 1990-08-22 | — | — | EP | disclosed |