Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.66 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.61 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.53 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.51 |
| ▸ | DPP4 | P27487 | 4/20 | 0.51 |
| ▸ | RRM1 | P23921 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27789284 | 1.00 | DPP7 (0.66) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL4824669 | 0.98 | DPP7 (0.64) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL25015353 | 0.95 | DPP7 (0.64) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL7306160 | 0.84 | DPP7 (0.74) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL22369853 | 0.84 | GNAI3 (0.59) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL13752034 | 0.84 | DPP7 (0.74) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL24907137 | 0.82 | DPP7 (0.72) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL5673337 | 0.81 | DPP7 (0.89) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL3806649 | 0.81 | DPP7 (0.82) | DPP7SLC15A1GNAI3GNAO1GNAI1 | |
| SCHEMBL7277162 | 0.81 | EPHX1 (0.50) | DPP7SLC15A1EPHX1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101781268-B | Isothiazolone substituted benzene dicarboxylic acid derivatives and their use for preparing beta-secretase inhibitors | INST PHARM & TOXICOLOGY AMMS | 2012-05-30 | — | — | CN | disclosed |
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |
| EP-1656359-A2 | MACROCYCLIC BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2005018545-A2 | MACROCYCLIC BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | DPP7 349/4885SLC15A1 3312/4885GNAI3 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.