Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5278040 | 0.86 | KCNJ1 (0.36) | KCNJ1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8401872 | 0.85 | KCNJ1 (0.41) | KCNJ1ALDH1A1KMT2AMEN1ALPG | |
| SCHEMBL4502875 | 0.83 | — | — | |
| SCHEMBL707611 | 0.81 | — | — | |
| SCHEMBL8399476 | 0.78 | — | — | |
| SCHEMBL29110810 | 0.76 | — | — | |
| SCHEMBL28411403 | 0.74 | KCNJ1 (0.34) | KCNJ1MAPTPOLBBLMTDP1 | |
| SCHEMBL5277085 | 0.68 | KCNJ1 (0.30) | KCNJ1 | |
| SCHEMBL5280320 | 0.68 | KCNJ1 (0.30) | KCNJ1NOTUM | |
| SCHEMBL1472277 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221680-A | Controlling or prevention of diseases of the cardiovascular system | CASSELLA AKTIENGESELLSCHAFT (DE) | 1993-06-22 | — | — | US | disclosed |
| EP-0429751-B1 | SUBSTITUTED 3-AMINO-SYDNONIMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1993-06-16 | — | — | EP | disclosed |
| EP-0346694-B1 | SUBSTITUTED 3-AMINOSYDNONE IMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1993-01-27 | — | — | EP | disclosed |
| US-5179206-A | Cardiovascular disorders; angina pectoris; hypotensive agents | CASSELLA AKTIENGELLSCHAFT (DE) | 1993-01-12 | — | — | US | disclosed |
| US-5166166-A | Hypotensive agents or treatment of cardiovascular disorders | CASSELLA AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| US-5155109-A | Useful for control and prevention of hypertensive and/or angina pectoris | CASSELLA AKTIENGESELLSCHAFT (DE) | 1992-10-13 | — | — | US | disclosed |
| EP-0497122-A1 | Substituted 3-aminosydnonimines, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1992-08-05 | — | — | EP | disclosed |
| US-5120732-A | Treating cardiovascular disorders | CASSELLA AKTIENGESELLSCHAFT (DE) | 1992-06-09 | — | — | US | disclosed |
| EP-0367036-B1 | SUBSTITUTED 3-AMINOSYDNONIMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1992-04-29 | — | — | EP | disclosed |
| EP-0480241-A1 | 3-Piperazino-sydnonimines, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1992-04-15 | — | — | EP | disclosed |
| EP-0327808-B1 | SUBSTITUTED 3-AMINOSYDNONIMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1991-05-02 | — | — | EP | disclosed |
| US-5006540-A | Cardiotonic agents | CASSELLA AKTIENGESELLSCHAFT (DE) | 1991-04-09 | — | — | US | disclosed |
| EP-0406659-A1 | Substituted 3-aminosydnonimines, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1991-01-09 | — | — | EP | disclosed |
| EP-0406661-A1 | Substituted 3-aminosydnonimines, process for their preparation, and their use | CASSELLA Aktiengesellschaft (DE) | 1991-01-09 | — | — | EP | disclosed |
| US-4937244-A | HYPOTENSIVE AND CARDIOTONIC AGENTS; ANGINA PECTORIS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1990-06-26 | — | — | US | disclosed |
| EP-0367036-A2 | Substituted 3-aminosydnonimines, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1990-05-09 | — | — | EP | disclosed |
| EP-0346684-A1 | Substituted 3-aminosydnonimines, method for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0346694-A1 | Substituted 3-Aminosydnone imines, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0327808-A1 | Substituted 3-aminosydnonimines, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1989-08-16 | — | — | EP | disclosed |
| EP-0312773-A2 | Substituted 3-aminosydnonimines, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1989-04-26 | — | — | EP | disclosed |